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Sunday, February 21, 2010

Clogged Arteries - Remove Artery Plaque - Liquid Arginine Supplement -

Good Life International Distributor
Leslie Turner

Researchers are already aware that consuming a diet high in fat can lead to heart disease – but now they know a little bit more about how this whole process works. Put that information to work for you in getting your Clogged Arteries healthy again.

A study at the University of Cincinnati looked at high-fat diets and the effect they have on the tissue around human blood vessels.

First, in a laboratory study, the researchers found fat had the ability to inflame human fat cells, which in turn could cause the blood vessels to become inflamed and lead to clogged arteries.

Then, in an animal study, they discovered that feeding mice a high-fat diet for just two weeks was enough to provoke inflammation in the tissue around the arteries.

“These new findings suggest a direct link between poor dietary habits and inflammation of blood vessels, mediated by the fat cells surrounding the blood vessel wall,” commented lead author Dr. Neal Weintraub.

Earlier studies have linked inflammation to a higher risk of developing heart disease.

Oral chelation is one method some people use to help maintain healthy blood pressure and boost heart health.

Learn all you Can about the Nobel Prize Winning Research of L-Arginine and Give your Arteries a Fighting Chance.

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Prevent and Reverse Heart Disease with the Knowledge of L-Arginine. Leslie Turner - Good Life International

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Eating to Live Heart Smart Book Excerpts

“It was a Friday in November 1996. I had operated all day. I finished, said good-bye to my last patient, and got a very, very bad headache. It hit me in a flash. I had to sit down. A minute or two after that, the chest pain started. It radiated up my arm and shoulder and into my jaw.”

These are the words of Joe Crowe, the doctor who succeeded me as chairman of the breast cancer task force at the Cleveland Clinic. He was having a heart attack. He was only forty-four years old. He had no family history of heart disease, was not overweight or diabetic, and did not have high blood pressure or a bad cholesterol count. In short, he was not the usual candidate for a heart attack. Nonetheless, he had been struck—and struck hard.

In this book, I tell Joe Crowe’s story, along with those of many other patients I have treated over the past twenty years. My subject is coronary artery disease, its cause, and the revolutionary treatment, available to all, that can abolish it and that has saved Joe Crowe and many others.

My message is clear and absolute: coronary artery disease need not exist, and if it does, it need not progress. It is my dream that one day we may entirely abolish heart disease, the scourge of the affluent, modern West, along with an impressive roster of other chronic illnesses.

Here are the facts. Coronary artery disease is the leading killer of men and women in Western civilization. In the United States alone, more than half a million people die of it every single year. Three times that number suffer known heart attacks.

And approximately three million more have “silent” heart attacks, experiencing minimal symptoms and having no idea, until well after the damage is done, that they are in mortal danger. In the course of a lifetime, one out of every two American men and one out of every three American women will have some form of the disease.

The cost of this epidemic is enormous—greater, by far, than that of any other disease. The United States spends more than $250 billion a year on heart disease. That’s about the same amount the nation spent on the first two and half years of its military venture in Iraq, and fully twice as much as the federal government allocates annually for all research and development—including R&D for defense and national security.
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But here is the truly shocking statistic: nearly all of that money is devoted to treating symptoms. It pays for cardiac drugs, for clot-dissolving medications, and for costly mechanical techniques that bypass clogged arteries or widen them with balloons, tiny rotating knives, lasers, and stents. All of these approaches carry significant risk of serious complications, including death. And even if they are successful, they provide only temporary relief from the symptoms.

They do nothing at all to cure the underlying disease or to prevent its development in other potential victims.

I believe that we in the medical profession have taken the wrong course. It is as if we were simply standing by, watching millions of people march over a cliff, and then intervening in a desperate, last-minute attempt to save them once they have fallen over the edge. Instead, we should be teaching them how to avoid the chasm entirely, how to walk parallel to the precipice so that they will never fall at all.

I believe that coronary artery disease is preventable, and that even after it is underway, its progress can be stopped, its insidious effects reversed. I believe, and my work over the past twenty years has demonstrated, that all this can be accomplished without expensive mechanical intervention and with minimal use of drugs.

The key lies in nutrition—specifically, in abandoning the toxic American diet and maintaining cholesterol levels well below those historically recommended by health policy experts.

The bottom line of the nutritional program I recommend is that it contains not a single item of any food known to cause or promote the development of vascular disease. I often ask patients to compare their coronary artery disease to a house fire.

Your house is on fire because eating the wrong foods has given you heart disease. You are spraying gasoline on the fire by continuing to eat the very same foods that caused the disease in the first place.

I don’t want my patients to pour a single thimbleful of gasoline on the fire. Stopping the gasoline puts out the fire. Reforming the way you eat will end the heart disease.

Here are the rules of my program in their simplest form:

• You may not eat anything with a mother or a face (no meat, poultry, or fish).

• You cannot eat dairy products.

• You must not consume oil of any kind—not a drop. (Yes, you devotees of the Mediterranean Diet, that includes olive oil, as I’ll explain in Chapter 10.)

• Generally, you cannot eat nuts or avocados.

You can eat a wonderful variety of delicious, nutrient-dense foods:

• All vegetables except avocado. Leafy green vegetables, root vegetables, veggies that are red, green, purple, orange, and yellowand everything in between

• All legumes—beans, peas, and lentils of all varieties.

• All whole grains and products, such as bread and pasta, that are made from them—as long as they do not contain added fats.

• All fruits.

It works. In the first continuous twelve-year study of the effects of nutrition in severely ill patients, which I will describe in this book, those who complied with my program achieved total arrest of clinical progression and significant selective reversal of coronary artery disease. In fully compliant patients, we have seen angina disappear in a few weeks and abnormal stress test results return to normal.

And consider the case of Joe Crowe. After his heart attack in 1996, tests showed that the entire lower third of his left anterior descending coronary artery—the vessel leading to the front of the heart and nicknamed, for obvious reasons, “the widowmaker”—was significantly diseased. His coronary artery anatomy excluded him as a candidate for surgical bypass, angioplasty, or stents, and at such a young age, with a wife and three small children, Dr. Crowe was understandably disconsolate and depressed.

Since he already exercised, did not use tobacco, and had a relatively low cholesterol count of 156 milligrams per deciliter (mg/dL), there seemed to be nothing he could modify, no obvious reforms in lifestyle that might halt the disease.

Joe was aware of my interest in coronary disease. About two weeks after his heart attack, he and his wife, Mary Lind, came to dinner at our house and I had a chance to share the full details of my research.

Both Joe and Mary Lind immediately grasped the implications for Joe of a plant-based diet. All at once, instead of having no options, they were empowered. In Mary Lind’s words, “It was our own personal disaster, and suddenly there was something small we could do.”

Immediately, Joe embarked on my nutrition program, refusing to take any cholesterol-lowering drugs, and he redefined the word commitment. He stuck to the plan rigorously, eventually reducing his total blood cholesterol count to just 89 mg/dL and cutting his LDL, or “bad” cholesterol, from 98 mg/dL to 38 mg/dL.

About two and a half years after Joe adopted a strict plant-based diet, there came a point when he was exceptionally busy professionally, under considerable stress, and he noted a return of some discomfort in his chest. His cardiologists, worried about the recurrence of angina, asked for more tests to see what was going on.

On the day of his follow-up angiogram, I went to Dr. Crowe’s office after work. After we greeted each other, I thought I saw moisture in his eyes. “Is everything OK?” I asked.

“You saved my life,” he declared. “It’s gone! It’s not there anymore! Something lethal is gone! My follow-up angiogram was normal.”

Nearly ten years later, Mary Lind recalled that they had wondered, that first evening at our house, “how the Esselstyns did it”— how we had managed to completely change the way we eat. “Now it’s part of our family,” she says. “We’ve eaten the same things for a long time, and I’m on autopilot.”

Later, when I asked Joe what made him decide to change, he responded very simply. “We believed you,” he said, and added, “since I had nothing else, the diet came first. If I had had bypass surgery, diet would not have been first. The diet set us on another path, empowered to do something we knew we could do.”

Joe Crowe’s angiograms—both the original, taken after the heart attack, and the follow-up, two and a half years later. It is the most complete resolution of coronary artery disease I have seen, graphic proof of the power of plant-based nutrition to enable the body to heal itself.

The dietary changes that have helped my patients over the past twenty years can help you, too. They can actually make you immune to heart attacks.

And there is considerable evidence that they have benefits far beyond coronary artery disease. If you eat to save your heart, you eat to save yourself from other diseases of nutritional extravagance: from strokes, hypertension, obesity, osteoporosis, adult-onset diabetes, and possibly senile mental impairment, as well.

You gain protection from a host of other ailments that have been linked to dietary factors, including impotence and cancers of the breast, prostate, colon, rectum, uterus, and ovaries. And if you are eating for good health in this way, here’s a side benefit you might not have expected: for the rest of your life, you will never again have to count calories or worry about your weight.

An increasing number of doctors are aware that diet plays a crucial role in health, and that nutritional changes such as those I recommend can have dramatic effects on the development and progression of disease. But for a number of reasons, current medical practice places little emphasis on primary and secondary prevention.

For most physicians, nutrition is not of significant interest. It is not an essential pillar of medical education; each generation of medical students learns about a different set of pills and procedures, but receives almost no training in disease prevention. And in practice, doctors are not rewarded for educating patients about the merits of truly healthy lifestyles.

Over the past one hundred years, the mechanical treatment of disease has increasingly dominated the medical profession in the United States. Surgery is the prototype, and its dramatic progress— light-years removed from the cathartics, bloodletting, and amputations that dominated medicine in previous centuries—is nothing short of breathtaking.

But surgery has serious flaws. It is expensive, painful, and frightening, often disabling and disfiguring, and too often merely a temporary stopgap against the disease it is intended to treat. It is a mechanical approach to a biological problem.

Perhaps no area of medicine better illustrates the mechanical approach to disease than cardiology and cardiac surgery. Consider: the United States contains just 5 percent of the global population, but every year, physicians in American hospitals perform more than 50 percent of all the angioplasties and bypass procedures in the entire world.

One reason is that mechanical medicine is romantic and dramatic, a natural magnet for media attention. Remember the drama several years ago surrounding implants of artificial hearts? Most of the recipients died within weeks of their surgery, and all lived their last days tethered to life-support machinery that, far from enhancing their quality of life, drastically reduced it. But no matter: the dramatic interventions engaged the national imagination for months on end.

All told, there has been little incentive for physicians to study alternate ways to manage disease, so the mechanical/procedural approach continues to dominate the profession even though it offers little to the unsuspecting millions about to become the next victims of disease. Modern hospitals offer almost nothing to enhance public health. They are cathedrals of sickness.

There are some signs of change. Physicians and researchers increasingly agree that lifestyle changes—controlling blood pressure, stopping smoking, reducing cholesterol, exercising, and modifying diets—are essential to overall health. It is hard to deny the evidence, mounting with every passing year, that people who have spent a lifetime consuming the typical American diet are in dire trouble.

Dr. Lewis Kuller of the University of Pittsburgh recently reported the ten-year findings of the Cardiovascular Health Study, a project of the National Heart, Lung, and Blood Institute. His conclusion is startling: “All males over 65 years of age, exposed to a traditional Western lifestyle, have cardiovascular disease and should be treated as such.”
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Even interventional cardiologists are beginning to question the rationale of their procedures. In 1999, cardiologist David Waters of the University of California performed a study that compared the results of angioplasty—in which a balloon is inserted into a coronary artery to widen the vessel and improve blood flow—with the use of drugs to aggressively reduce serum cholesterol levels. There was no disputing the outcome.

The patients who had the drug treatment to lower cholesterol had fewer hospitalizations for chest pain and fewer heart attacks than those who underwent angioplasty and standard postoperative care.3

The larger lesson of that study is that systemic treatment of disease through aggressive reduction of cholesterol is clearly superior to selective intervention at a single site where an artery has been clogged and narrowed. And it caused considerable uproar among cardiologists. As Dr. Waters observes, “There is a tradition in cardiology that doesn’t want to hear that.”

Why? Money! For many years, I resisted that conclusion, but the weight of the evidence is overwhelming. Interventional cardiologists earn hundreds of thousands of dollars annually, and particularly busy ones make millions.

In addition, cardiology procedures generate huge revenues for hospitals. And the insurance industry supports the mechanical/procedural approach to vascular disease. It is far easier to document and quantify procedures for reimbursement than it is to document and quantify lifestyle changes that prevent the need for such procedures in the first place.

As a physician, I am embarrassed by my profession’s lack of interest in healthier lifestyles. We need to change the way we approach chronic disease.

The work I will describe in the following chapters confirms that sustained nutrition changes and, when necessary, low doses of cholesterol-reducing medication will offer maximum protection from vascular disease. Anyone who follows the program faithfully will almost certainly see no further progression of disease, and will very likely find that it selectively regresses.

And the corollary, overwhelmingly supported by global population studies, is that persons without the disease who adopt these same dietary changes will never develop heart disease.

Cardiologists who have seen my peer-reviewed data often concede that coronary artery disease may be arrested and reversed through changes in diet and lifestyle, but then add that they don’t believe their patients would follow such “radical” nutritional changes. But the truth is that there is nothing radical about my nutrition plan. It’s about as mainstream as you can get. For 4 billion of the world’s 5.5 billion people, the nutrition program I recommend is standard fare, and heart disease and many other chronic ailments are almost unknown.

The word radical better describes the typical American diet, which guarantees that millions will perish from withering vascular systems. And in my experience, patients who realize that they have a clear choice—between invasive surgery that will do nothing to cure their underlying disease and nutritional changes that will arrest and reverse the disease and improve the quality of their lives—willingly adopt the dietary changes.

One of my patients, Jerry Murphy, came to me at the age of sixty-seven after his cardiologist recommended open heart surgery, something he was determined to avoid. “No male Murphy has ever lived beyond sixty-seven,” he announced. “What are you going to do about that?” I responded that the real question was what hewas going to do about it, albeit with my help.

Now in his mid-eighties—well past the sixty-seven-year life expectancy for male Murphys—Jerry Murphy thinks my nutrition program represents a more natural way of eating, a return to healthier ways of the past. “It made sense to me,” he says, citing his Irish ancestors, who may have killed the fatted calf once a year, but who subsisted primarily on a low-fat, plant-based diet.

Each of us has friends, family, and acquaintances who are the victims of coronary disease. These people are often vigorous, in the prime of life, when they are struck down by a heart attack. If they survive, they are rarely the same again, always fearful of another attack or the onset of some complication. Those close to them share similar concerns.

But the truth is that this disease need never occur at all. For the great majority of this planet’s population—the 4 billion who do not participate in the Western lifestyle—it simply does not exist.""

Source of Post and to Buy Dr. Caldwell B. Esselstyn, Jr., MD Book from Him Click Below
http://www.heartattackproof.com/excerpt.htm

Leslie Turner Montana
Good Life International
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Good Life International - Arginine Supplement - America's New Cardio-Enhancing Supplement

Excerpt From The Arginine Solution By Robert Fried.

In the field of medicine and health it is one of the revolutions of our time: the discovery that the amino acid L-Arginine may be a "magic bullet" for the cardiovascular system.

Now, as the evidence mounts, including research that recently won the Nobel Prize in Medicine, more and more scientists and doctors see the extraordinary health benefits of increasing L-Arginine intake.

A virtual arterial cleanser, L-Arginine helps eliminate blockage and maintain blood flow.

In this persuasive, groundbreaking book, Robert Fried, Ph.D., and Woodson C. Merrell, M.D., two renowned New York health experts, make the case for making L-Arginine part of your life, while also pointing out the situations in which elevated intake may be contraindicated.

The Arginine Solution offers the research and clinical evidence that proves the effectiveness of L-Arginine in raising the body's production of nitric oxide, a principal blood pressure regulator. L-Arginine, an amino acid available in inexpensive supplement form, can have a powerful impact on your cardiovascular health. In addition, as it helps increase blood flow throughout the body.
L-Arginine can also boost...

• the immune system

• mental acuity

• and weight loss

while it reduces the harmful effects of...

• aging

• diabetes

• asthma

and many other conditions.

Drawing on the latest research, case histories, and their own experience, Drs. Robert Fried and Woodson C. Merrell have written a book that can improve the quality of life for many and even save lives - with a reliable, natural substance that plays an essential role in human health and longevity.

A Few Grams of Prevention
The New Supplemental Safeguard for Your Good Health
Here's a double health to thee! - Lord Byron

If you're now reading these words, chances are you take your own health, and that of your loved ones, very much to heart. The ancient Greek physician Hippocrates called health "the greatest of human blessings," a sentiment that has been echoed by poets and philosophers throughout the ages. Health is today, as it has always been, the only currency whose 2 presence or absence can make the poor rich, and the rich poor.

"Give me health and a day," declared Ralph Waldo Emerson, "and I will make the pomp of emperors ridiculous."

Never before in human history has mankind understood so much about the multiple processes that preserve our well being, or rob us of it. From genetic engineering to pioneering brain research to potential cures for cancer, we stand poised at the threshold of a new era, a time when countless scourges that have so long afflicted our species are finally beginning to yield to unprecedented scientific investigation. Researchers the world over are increasing the knowledge base at an exponential rate.

Sometimes it almost seems as if disease itself has become an endangered species.
But the same technological revolution that, with its right hand, forges new hope for cures is, with its left hand, foisting upon all too many of us the need for such cures.

Consider this: For our ancestors in antiquity, food was rarely plentiful and obtaining it almost always required great physical effort. Modern life, on the other hand, has put the "ease" into disease. Today, we can lie on the sofa, TV remote control in one hand and cell phone in the other, and dial up a double-cheese pepperoni pizza for speedy home delivery.

The seductiveness of fast food, employment that requires long hours in sedentary pursuits, daily stresses for which the age-old "fight or flight" response can rarely be exercised without inviting trouble, a surfeit of cigarettes and alcohol and various drugs that are all too easily obtainable:

These are but a few of the hallmarks of industrialized society for which our hard scrabble evolution as a species has ill prepared us. No wonder that so-called lifestyle disorders - heart disease, high blood pressure, strokes, diabetes, many forms of cancer, and so on - continue to fell so many of us every year.

Make no mistake: These are hardly over-hyped conditions that only target "the other guy." An astonishing 7.5 percent of all American adults alive today have suffered a heart attack or periodic chest pains from heart disease. That's one out of every thirteen adults!

Even as medical researchers look for new ways to undo such damage once it's been wreaked, others look for ways to intercept disease before it's sunk its harpy claws too deeply into our flesh. In recent years, modern medicine has seen a resurgence of interest in integrative medicine - an approach that combines the best of the "fix what's broken" philosophy of conventional modern health care with the "preemptive strike" philosophy long embraced by alternative medicine healers and preventative medicine specialists alike.

Perhaps you, or someone you love, are now suffering from some kind of broken part. Maybe you've been diagnosed with coronary artery disease, high blood pressure, adult-onset diabetes, impotence, or any one of a long list of terribly common health problems. There is nothing like the loss of good health to compel a keen interest in doing everything possible to foster its return.

You Need Arginine, Find Out More and Find a Liquid L-Arginine to Supplement your Diet, make sure that it has L-Citrulline for the best absorbtion and that the form of L-Arginine that you take is 4-6 grams per day as recommended in the Nobel Prize winning Research by Dr. Louis Ignarro. Find the Best Price - the Best Product and Make L-Arginine a Part of Your Life.. I sure was and am glad that I Did.


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Friday, January 8, 2010

Arginine and the role of this Amino Acid in Reducing High Blood Pressure Naturally.

Arginine Can Lower Your Blood Pressure

Hypertension Sufferers do See Results from Arginine supplements. I am not a doctor or giving you medical advice of any kind, however, there is tons of research out there that claims the Amino Acid L-Arginine Can Lower your Blood Pressure.

Why Risk the horrible side affects of prescription drugs if something naturally really can reverse Hypertension and High Blood Pressure.


What Can Cause High Blood Pressure?

Most cases of high blood pressure have no noticable medical cause and are referred to as essential or primary, hypertension. Doctors still don't know what causes this most common type of hypertension, current research indicates that a complex interaction between genetic, environmental, and other variables is a significant factor.

Hypertension, which is much less common, is high blood pressure caused by known medical conditions, such as kidney disease, pregnancy, and sleep apnea.

Hypertension Can Do Permanent Damage

The real problem arises when blood pressure is elevated over a period of years or decades. Over such a time span, hypertension can cause significant damage to blood vessels that supply life-giving oxygen and nutrients to all parts of the body. The heart, brain, and kidneys, along with all other major body parts, can suffer irreparable harm from long-term hypertension.

Hypertension Is a very Big Business for Drug Companies

So many people have hypertension that the drug companies have introduced a tons of medications to control it. Studies have shown that many of the most heavily prescribed medications in the United States are antihypertensives. With drug costs rising at least 12% per year since 1993, patients, especially the elderly, can end up spending thousands of dollars a year on prescription drugs to control their blood pressure. While the majority of these drugs (including diuretics, calcium channel blockers, and ACE inhibitors) work well, they can have troublesome to potentially deadly side effects, including hyperglycemia (high blood glucose), tinnitus (constant ringing or buzzing in the ears), kidney damage, and heart failure.

Hypertension Can Be Controlled Naturally

For those who hesitate to use antihypertensive drugs for whatever reason, nondrug strategies may significantly help in controlling high blood pressure. The Dietary Approaches to Stop Hypertension (DASH) diet is now recommended as a first-line approach in managing the disease. The DASH diet is high in fruits, vegetables, and other nutritious foods that are rich in potassium, calcium, and magnesium.

People following the DASH diet are encouraged to decrease their saturated fats and replace them with foods that are high in monounsaturated fats and omega-3 fatty acids.

Other natural ways to control hypertension include not smoking and obesity control.

Another important nutrients in the role of reversing Hypertension and High Blood Pressure is the Amino Acid Arginine - The Source of Nitric Oxide.

L-Arginine Supplementation is a natural way to help improve blood pressure is with nutritional supplements. Arginine, an amino acid that is vitally important for overall good health, may be a potent weapon in the fight against hypertension. Besides playing a positive role in blood pressure control, arginine (technically, L-arginine, but the L can be taken for granted) can also be helpful in a variety of other conditions, including type 2 diabetes and sexual dysfunction in both women and men.

So how does arginine work its wonders? The answer lies in its ability to produce nitric oxide (NO), a simple gas made up of nitrogen and oxygen that performs some amazing feats in the human body. In fact, NO is such an important molecule that the 1998 Nobel Prize in Medicine was given to three scientists for their pioneering research on its role in human physiology.

Nitric oxide penetrates and crosses the membranes of almost all cells in the body, and it helps regulate many cellular functions. It is even involved in memory function. In blood vessels, NO is vitally important because it regulates the tone of the endothelium, the layer of smooth cells that line the inside of the vessels. If these endothelial cells become dysfunctional, they can cause spasms or constrictions of the blood vessels that can then lead to hypertension.

Arginine Reduces Blood Pressure in Healthy Adults

More and more studies are being published showing the beneficial effects of arginine supplementation on blood pressure. A recent study in Italy examined blood pressure changes among six healthy male volunteers who were placed on three different diets.

The first diet consisted of foods that contained 3 to 4 grams of arginine per day.

The second diet was high in arginine-rich foods (nuts and legumes), so that these volunteers consumed about 10 grams of arginine daily. The third diet was the same as the first, except for the addition of 10 grams of supplemental arginine daily.

After only one week, the men on both diets 2 and 3 registered significant decreases in blood pressure compared to those on diet 1. Interestingly, a statistically significant reduction in blood glucose (blood sugar) was also seen in the men on diet 2 or diet 3. Although the authors readily admit that the study had serious limitations (the short duration and the small number of subjects), they concluded that "the present study indicates that an approximately two-fold increase in dietary L-arginine intake had significant hemodynamic and metabolic effects in a group of healthy men."

Arginine Reduces Blood Pressure in Diabetics

People who suffer from diabetes have an increased risk for developing coronary artery disease, of which high blood pressure is often a significant component. Scientists are now looking at how arginine might help people with diabetes, in terms of both reducing their blood pressure and helping their bodies use insulin more efficiently.

A recent study examined the effects on blood pressure when arginine was given to six patients with type 2 (age-related) diabetes and hypertension.3 They received 3 grams of arginine every hour for 10 hours on either day 2 or day 3 of the study. On both of these days, their blood pressure was monitored for the same 10 hours. The results showed that the patients' systolic and diastolic pressures were significantly reduced only 2 hours after they started taking arginine.

Resources for More Study on Arginine and High Blood Pressure.

http://www.life-enhancement.com/article_template.asp?ID=780

http://www.youtube.com/watch?v=L5Urvyc8TUY


References on L-Arginine and High Blood Pressure Studies

Calvert, JF. Cardiovascular disease and hypertension. Clinics Fam Pract 2001;3(4):733-56.
Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hyperten 2000;13:547-51.

Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;5:422-7.

Piatti P, Monti LD, Vilsecchi G, et al. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diab Care 2001;24:875-80.
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Arginine Therapy, L-Arginine and Pulmonary Hypertension - Sickle Cell Disease

"A New Treatment for Pulmonary Hypertension in Sickle Cell Disease?

Pulmonary hypertension is a life-threatening complication of sickle cell disease. L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. This deficiency may play a role in pulmonary hypertension.

The enzyme arginase hydrolyzes arginine to ornithine and urea, and thus, it may compete with nitric oxide synthase, leading to decreased nitric oxide production.

Nitric oxide therapy by inhalation has improved pulmonary hypertension associated with acute chest syndrome in sickle cell disease, and several studies demonstrate therapeutic benefits of arginine therapy for primary and secondary pulmonary hypertension.

We sought to determine the effects of arginine therapy on pulmonary hypertension in patients with sickle cell disease. Arginase activity was also determined. Oral arginine produced a 15.2% mean reduction in estimated pulmonary artery systolic pressure (63.9 ± 13 to 54.2 ± 12 mm Hg, p = 0.002) after 5 days of therapy in 10 patients.

Arginase activity was elevated almost twofold (p = 0.07) in patients with pulmonary hypertension and may limit arginine bioavailability. With limited treatment options and a high mortality rate for patients with sickle cell disease who develop pulmonary hypertension, arginine is a promising new therapy that warrants further investigation.

Key Words: pulmonary hypertension • L-arginine • nitric oxide • sickle cell disease • arginase

Pulmonary hypertension is a life-threatening complication of sickle cell disease (1) that has been reported to occur in up to 30% of adult patients (1, 2). With improved medical care and a longer life expectancy, the number of affected patients will likely increase with time. The etiology of sickle cell disease–related pulmonary hypertension is unclear. Treatment options are limited, and the prognosis is poor (3). Patients who develop this complication have a shortened survival period (4). Its presence is an independent predictor of death, with an average time to death after diagnosis being as short as 12 months (2). Anecdotal treatments with vasodilators, oxygen, anticoagulants, and transfusion have been tried but remain unproven (3, 5).

Several studies in non–sickle cell disease patients demonstrate therapeutic benefits of L-arginine therapy for pulmonary hypertension (6, 7). Low plasma L-arginine concentrations have been discovered in infants with persistent pulmonary hypertension of the newborn (8) correlating with low nitric oxide metabolite levels (9). L-Arginine infusion has decreased pulmonary vascular resistance and improved blood oxygenation in infants with this disease process (10). L-Arginine supplementation also improves pulmonary artery pressures and hemodynamics in patients with primary and secondary pulmonary hypertension (7), and one recent study demonstrates these effects after only 1 week of therapy (6).

Inhalation of nitric oxide also lowers pulmonary artery pressures in both adults and infants with pulmonary hypertension (11, 12). Recent studies suggest that rapid scavenging of nitric oxide by cell-free hemoglobin, which is found in high concentrations under conditions of hemolysis, may limit nitric oxide bioavailability in sickle cell disease (13), whereas inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin (14). Several case reports have also demonstrated significant improvement in pulmonary hypertension in children with acute chest syndrome after inhaled nitric oxide therapy (15, 16).

Recent studies found that oral L-arginine normalizes red blood cell density and induces Gardos channel inhibition in sickle cell transgenic mice (17). There is otherwise limited information available on the impact of L-arginine supplementation in sickle cell disease (18).

However, improvement in pulmonary artery pressures has been described after treatment with arginine-butyrate in patients with sickle cell disease and pulmonary hypertension who were on hydroxyurea therapy (19). L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis (20–22). Because nitric oxide generation is increased by hydroxyurea (23–26), treatment with hydroxyurea may deplete arginine stores even further.

Therefore, it is possible that the arginine component of arginine-butyrate may possess therapeutic properties by replenishing the deficient substrate for nitric oxide production.

There is growing evidence that pulmonary hypertension is a disease process that involves altered arginine metabolism or decreased bioavailability. Arginase, an enzyme that converts L-arginine to ornithine and urea (27, 28), may limit nitric oxide bioavailability in sickle cell disease through increased use of its substrate. Because arginine supplementation improves pulmonary artery pressures in nonsickle cell patients with pulmonary hypertension (6, 7, 10), arginine may also be therapeutic for sickle cell disease patients with pulmonary hypertension by providing increased substrate for nitric oxide production. "

Full Article and Source Click Below
http://ajrccm.atsjournals.org/cgi/content/full/168/1/63
Arginine Drink

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Dr. Joe on L-Arginine - Severe Atherosclerosis - Get Rid of Calcium, Plaque on Your Arteries

Cardiovascular Unit Stanford.
Getting Rid of Calcium in Your Arteries.
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What Can Nitric Oxide can do for Your Health - Boost Nitric Oxide with L-Arginine Supplements

Louis Ignarro, Ph.D., Nobel† Laureate says that Nitric Oxide is like a trip to the gym for your cardiovascular system.

With heart health a leading concern among both men and women in America, you need every advantage you can get in protecting yourself from Cardiovascular Disease. The discovery of an amazing molecule, nitric oxide (NO), can help provide you with protection for your heart, your arteries and has even been said to be able to Reverse Heart Disease and Dissolve Artery Plaque.

Nitric Oxide improves circulation by helping your blood vessels to signal the surrounding smooth muscle to relax–which widens the arteries, increases blood flow and helps maintain normal blood pressure. Nitric Oxide keeps your system youthful, toned, and flexible.

In fact, optimizing NO production is like giving your cardiovascular system a workout every day! In addition to its numerous heart-health benefits, NO also promotes immune-system health and acts as a neurotransmitter.

Unfortunately, a large percentage of people are deficient in their ability to produce Nitric Oxide, which puts them at increased risk of Cardio Vascular Disease.

Using amino acids like L-arginine and L-citrulline, as well as antioxidants, you can actually increase your body’s own production of Nitric Oxid.

Learn All you Can about the Research of L-Arginine and Get Started on an Argine Supplement Today. Buy Liquid L-Arginine with L-Citrulline and lots of other powerful antioxidants Click HERE .
Boost Nitric Oxide with L-Arginine Supplements

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